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Chemical Structure : MR837
CAS No.: 1210906-48-1
Catalog No.: PC-72292Not For Human Use, Lab Use Only.
MR837 (NSD2-PWWP1 inhibitor 3f) is a small-molecule antagonist (inhibitor) that binds to the NSD2-PWWP1 domain (SPR Kd=3.4 uM, NSD2 IC50=17.3 uM), abrogates histone H3K36me2 binding to the PWWP1 domain in cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | $458 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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MR837 (NSD2-PWWP1 inhibitor 3f) is a small-molecule antagonist (inhibitor) that binds to the NSD2-PWWP1 domain (SPR Kd=3.4 uM, NSD2 IC50=17.3 uM), abrogates histone H3K36me2 binding to the PWWP1 domain in cells.
MR837 (NSD2-PWWP1 inhibitor 3f) decreased the interaction of NSD2-PWWP1 but not NSD3-PWWP1 with histone 3 in cells in a dose-dependent manner with an IC50 of 17.3 uM.
| M.Wt | 282.361 | |
| Formula | C16H14N2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (2.8 mg/mL) |
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| Chemical Name/SMILES |
Benzamide, 4-cyano-N-cyclopropyl-N-(2-thienylmethyl)- |
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1. Renato Ferreira de Freitas, et al. J Med Chem. 2021 Feb 11;64(3):1584-1592.
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