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Chemical Structure : MRT-83 hydrochloride
Catalog No.: PC-62174Not For Human Use, Lab Use Only.
MRT-83 hydrochloride is a potent Smoothened antagonist that blocks Hedgehog (Hh) signaling in various assays with IC50 of 10 nM.
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MRT-83 hydrochloride is a potent Smoothened antagonist that blocks Hedgehog (Hh) signaling in various assays with IC50 of 10 nM; inhibits Bodipy-cyclopamine binding to human and mouse Smo but does not modify Wnt signaling, blocks BC binding to HEK-hSmo cells with IC50 of 4.6 nM; abrogates the agonist-induced trafficking of endogenous mouse or human Smo, efficiently antagonizes Hh signaling in vivo.
| M.Wt | 575.062 | |
| Formula | C31H31ClN4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Roudaut H, et al. Mol Pharmacol. 2011 Mar;79(3):453-60.
2. Solinas A, et al. J Med Chem. 2012 Feb 23;55(4):1559-71.
3. Lauressergues E, et al. Pharmacol Res Perspect. 2016 Mar 4;4(2):e00214.
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