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Chemical Structure : MRT-92
Catalog No.: PC-20089Not For Human Use, Lab Use Only.
MRT-92 is a potent selective Smoothened (Smo) receptor antagonist (Kd=0.3 nM), inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation with IC50 of 0.4 nM.
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MRT-92 is a potent selective Smoothened (Smo) receptor antagonist (Kd=0.3 nM), inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation with IC50 of 0.4 nM.
MRT-92 blocked both SAG (0.1 µM) and GSA-10 (1 µM) induced differentiation of C3H10T1/2 cells with IC50 of 0.006 and 1 uM, respectively.
MRT-92 displayed an IC50 of 5.6 nM for SAG induction of AP response, selectively blocks SmoSAG-induced AP response in C3H10T1/2 cells.
MRT-92 abrogated Smo ciliary translocation promoted by SAG in primary cilium of NIH3T3 cells.
MRT-92 did not block Wnt signaling.
MRT-92 inhibited rat GCPs and Shh medulloblastoma cell proliferation.
| M.Wt | 566.66 | |
| Formula | C33H34N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lucile Hoch, et al. FASEB J. 2015 May;29(5):1817-29.
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