Chemical Structure : MS3-123
CAS No.:
MS3-123
Catalog No.: PC-27104Not For Human Use, Lab Use Only.
MS3-123 is a highly potent, selective and covalent inhibitor of PRMT1 with IC50 of 11.4 nM, targeting the unique Cys119 within the SAM-binding pocket of PRMT1.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MS3-123 is a highly potent, selective and covalent inhibitor of PRMT1 with IC50 of 11.4 nM, targeting the unique Cys119 within the SAM-binding pocket of PRMT1.
MS3-123 shows 17-96-fold selectivity against other type I PRMTs subfamily and >439-fold selectivity against type II PRMT5.
MS3-123 selectively engages Cys119, inhibiting PRMT1 activity at both enzymatic and cellular levels.
MS3-123 suppressed breast cancer cell proliferation, migration, invasion, induced cell cycle arrest and apoptosis, and impaired tumor growth in vivo in the MDA-MB-231-xenograft model.
Physicochemical Properties
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M.Wt
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455.80
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Formula
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C15H24BrClN4O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((5-bromo-4-((4-(dimethylamino)piperidin-1-yl)sulfonyl)-1-methyl-1H-pyrrol-2-yl)methyl)-2-chloroacetamide
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References
1. Shao M, et al. J Med Chem. 2026 Jun 17. doi: 10.1021/acs.jmedchem.6c00262.
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