Chemical Structure : MS479
CAS No.:
3088218-75-8
MS479
(MS-479)
Catalog No.: PC-28729Not For Human Use, Lab Use Only.
MS479 is a specific SPOP-recruiting BRD4 PROTAC degrader with DC50 of 6.2 uM, recruits the E3 ligase SPOP by directly binding its substrate GLP as a bridge protein, effectively reduces the protein level of BRD4 short isoform (BRD4 (S)) in a time-, concentration-, GLP-, SPOP-, and ubiquitin-proteasome system (UPS)-dependent manner.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MS479 is a specific SPOP-recruiting BRD4 PROTAC degrader with DC50 of 6.2 uM, recruits the E3 ligase SPOP by directly binding its substrate GLP as a bridge protein, effectively reduces the protein level of BRD4 short isoform (BRD4 (S)) in a time-, concentration-, GLP-, SPOP-, and ubiquitin-proteasome system (UPS)-dependent manner.
Physicochemical Properties
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M.Wt
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1092.89
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Formula
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C59H82ClN11O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-N-(10-(2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4] triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)decyl)-4-(4-((6-methoxy-2-morpholino-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)amino)piperidin-1-yl)butanamide
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References
1. Zhijie Deng, et al. J Med Chem. 2025 Apr 24;68(8):8634-8647.
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