Catalog No.: PC-22053Not For Human Use, Lab Use Only.
MS8535 is a potent, selective and cell-active inhibitor of methyl-lysine reader protein SPIN1 with biochemical IC50 of 202 nM and ITC binding Kd of 30 nM.
MS8535 is a potent, selective and cell-active inhibitor of methyl-lysine reader protein SPIN1 with biochemical IC50 of 202 nM and ITC binding Kd of 30 nM.
MS8535 displays high selectivity for SPIN1 over 38 epigenetic targets, including G9a/GLP, and >18-fold selective for SPIN1 over several other SPIN family members, such as SPIN2B (Kd = 0.56 μM), SPIN3 (Kd = 1.4 μM), and SPIN4 (Kd = 0.71 μM).
MS8535 concentration dependently blocks the interactions between SPIN1 and histone H3 in U2OS cells with EC50 of 1.1 uM in NanoBRET assay.
