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MT16-205

Chemical Structure : MT16-205

CAS No.: 1895051-79-2

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MT16-205 (MT 16-205)

Catalog No.: PC-72221Not For Human Use, Lab Use Only.

MT16-205 (MT 16-205) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 600 nM, no inhibition agianst UCHL3 (IC50>10 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MT16-205 (MT 16-205) is a potent, selective, covalent UCHL1 inhibitor with IC50 of 600 nM, no inhibition agianst UCHL3 (IC50>10 uM).
    MT16-205 inhibited both UCHL1 and the structurally unrelated DUB USP30 with similar potency.
    MT16-205 displayed cell proliferation cytotoxicity in human embryonic kidney cells (HEK293) with IC50 of 350 nM, MT16-205 effectively engaged UCHL1 in cells with IC50 of 830 nM.

    Physicochemical Properties

    M.Wt 322.386
    Formula C17H14N4OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-1-cyano-N-(5-(4-ethynylphenyl)thiazol-2-yl)pyrrolidine-3-carboxamide

    References

    1. Nattawadee Panyain, et al. RSC Med Chem. 2021 Aug 16;12(11):1935-1943.

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