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Chemical Structure : MT47-100
Catalog No.: PC-61181Not For Human Use, Lab Use Only.
MT47-100 is a novel potent, allosteric, simultaneously direct activator and inhibitor of AMPK complexes containing the β1 or β2 isoform, respectively.
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MT47-100 is a novel potent, allosteric, simultaneously direct activator and inhibitor of AMPK complexes containing the β1 or β2 isoform, respectively.
MT47-100 maximally activates α1β1γ1 approximately 2.5-fold with half-maximal activation Ka of 3.7 uM and activates all AMPKβ1 complexes regardless α or γ isoforms.
MT47-100 directly inhibits AMPKβ2 complexes independently of α or γ isoforms with Ki of 24.8 uM, this inhibition is dependent on the β2 carbohydrate-binding module (CBM) and independent of β2-Ser108 phosphorylation.
MT47-100 augmentes glucose-stimulated insulin secretion from isolated mouse pancreatic islets via a β2-dependent mechanism.
| M.Wt | 354.365 | |
| Formula | C22H14N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Scott JW, et al. Chem Biol. 2015 Jun 18;22(6):705-11.
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