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MTR-106

Chemical Structure : MTR-106

CAS No.: 1639357-93-9

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MTR-106 (MTR106)

Catalog No.: PC-26876Not For Human Use, Lab Use Only.

MTR-106 is a highly potent G-quadruplex stabilizer and RNA polymerase I inhibitor, stabilizes G4 sequences and inhibits rRNA synthesis, displays significant antiproliferative activity in homologous recombination repair (HR)-deficient and PARP inhibitor (PARPi)-resistant cancer cells.

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5 mg $148 In stock
10 mg $218 In stock
25 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MTR-106 is a highly potent G-quadruplex stabilizer and RNA polymerase I inhibitor, stabilizes G4 sequences and inhibits rRNA synthesis, displays significant antiproliferative activity in homologous recombination repair (HR)-deficient and PARP inhibitor (PARPi)-resistant cancer cells.

Physicochemical Properties

M.Wt 525.63
Formula C28H27N7O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

rel-2-((3aR,6aS)-5-Methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide

References

1. Li MZ, et al. Invest New Drugs. 2021 Oct;39(5):1213-1221.

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