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Chemical Structure : MU1300
Catalog No.: PC-35986Not For Human Use, Lab Use Only.
MU1300 (MU-1300) is novel effective, selective modulator of the Hedgehog (Hh) pathway, suppresses Hh-dependent osteogenesis with IC50 of 300 nM in osteoblast differentiation assay using C3H10T1/2 cells, targets and binds to Smoothened (Smo) directly.
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MU1300 (MU-1300) is novel effective, selective modulator of the Hedgehog (Hh) pathway, suppresses Hh-dependent osteogenesis with IC50 of 300 nM in osteoblast differentiation assay using C3H10T1/2 cells, targets and binds to Smoothened (Smo) directly.
MU1300 inhibited the GLI-mediated response with IC50 of 400 nM in GLI-dependent reporter gene assay using Shh-LIGHT2 cells.
MU1300 reduces the expression of the Hh target genes Gli1 and Ptch1 by 55% and 63% in NIH-3T3 cells in RT-qPCR analysis.
Only inhibits only 5 kinases to 40-60% at 10 uM in Thermo Fisher SelectScreen kinase panel (454 kinases).
| M.Wt | 300.376 | |
| Formula | C16H16N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Němec V, et al. Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1062-1066.
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