Chemical Structure : MW073
CAS No.:
3048608-87-0
MW073
(MW-073)
Catalog No.: PC-24324Not For Human Use, Lab Use Only.
MW073 is a highly selective and orally bioavailable inhibitor of 5-HT2b receptor (5-HT2bR) with binding IC50 of 70 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MW073 is a highly selective and orally bioavailable inhibitor of 5-HT2b receptor (5-HT2bR) with binding IC50 of 70 nM.
MW073 is serotonin 5-HT2bR activation and β-arrestin-1 recruitment with Kd of 89 nM for m5-HT2bR and 125 nM for h5-HT2bR, and Kb value of m5-HT2bR (73 nM) and h5-HT2bR (102 nM).
MW073 also inhibits basal constitutive activity for both species of 5-HT2bR.
MW073 exhibited only 5-HT2bR antagonist activity when subjected to large-scale cellular screening of 165 diverse GPCRs for agonist and antagonist activity.
MW073 protects against long-term potentiation (LTP) reduction by Aβ and tau oligomers.
MW073 ameliorates the RAWM and FC defects in a dose-dependent manner in APP/PS1 mice.
MW073 attenuates synaptic and behavioral dysfunctions an animal models of neuropsychatric syndromes.
Physicochemical Properties
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M.Wt
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361.49
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Formula
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C22H27N5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-methyl-N-(2-(4-methylpiperazin-1-yl)ethyl)-6-(naphthalen-2-yl)pyridazin-3-amine
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References
1. Roy SM, et al. Alzheimers Dement (N Y). 2025 Mar 27;11(1):e70073.
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