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Chemical Structure : MY-9B
Catalog No.: PC-49271Not For Human Use, Lab Use Only.
MY-9B is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.2 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory armadillo repeat (ARM) domain of SARM1.
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MY-9B is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.2 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory armadillo repeat (ARM) domain of SARM1.
MY-9B inhibits the NADase activity of WT-SARM1, but not C311A or C311S SARM1 mutants, show a high degree of proteome-wide selectivity for SARM1 C311.
MY-9B (10-20 uM) stereoselectively blocks vincristine- and vacor-induced neurite degeneration in primary rodent dorsal root ganglion neurons.
| M.Wt | 403.438 | |
| Formula | C23H21N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hannah C Feldman, et al. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2208457119.
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