Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : MYCi361
CAS No.: 2289690-31-7
Catalog No.: PC-73126Not For Human Use, Lab Use Only.
MYCi361 (NUCC-0196361) is a small molecule MYC inhibitor, binds to MYC protein with KD of 3.2 uM, disrupts MYC/MAX complex formation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $258 | In stock | |
| 50 mg | $658 | In stock | |
| 100 mg | $988 | In stock | |
| 250 mg | $1580 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MYCi361 (NUCC-0196361) is a small molecule MYC inhibitor, binds to MYC protein with KD of 3.2 uM, disrupts MYC/MAX complex formation.
MYCi361 impaired MYC/MAX heterodimer but not the closely related MAX/MAX homodimer binding to E-box DNA.
MYCi361 disrupts the MYC/MAX interaction in PC3 cells at concentration 6 μM for 1 hr.
MYCi361 decreases MYC protein stability by modulating MYC-threonine 58 phosphorylation.
MYCi361 inhibits cell proliferatin ona panel of MYC-dependent and -independent cell lines (LNCaP cell IC50 =1.4 uM, MV411, IC50=2.6 uM).
MYCi361 shows favorable pharmacokinetics and inhibits MYC-driven tumor growth in vivo.
MYCi361 modulates the tumor immune microenvironment and enhances anti-PD1 immunotherapy.
| M.Wt | 594.86 | |
| Formula | C26H16ClF9N2O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
6-((4-chlorobenzyl)oxy)-3-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-2-ol |
|
1. Han H, et al. Cancer Cell. 2019 Nov 11;36(5):483-497.e15.
2. Ding T, et al. Front Cell Dev Biol. 2021 Feb 26;9:644397.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
