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Chemical Structure : Marizomib
Catalog No.: PC-61315Not For Human Use, Lab Use Only.
A potent, orally bioactive 20S proteasome inhibitor with IC50 of 1.3 nM (inhibition of proteasomal chymotrypsin-like proteolytic activity).
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A potent, orally bioactive 20S proteasome inhibitor with IC50 of 1.3 nM (inhibition of proteasomal chymotrypsin-like proteolytic activity); displays 35 times more potent than omuralide; induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib, including chemical structure, effects on proteasome activities, mechanisms of action, and toxicity profile against normal cells; significantly reduces tumor recurrence in animal tumor model studies.
Blood Cancer
Phase 2 Clinical
| M.Wt | 313.781 | |
| Formula | C15H20ClNO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chauhan D, et al. Cancer Cell. 2005 Nov;8(5):407-19.
2. Feling RH, et al. Angew Chem Int Ed Engl. 2003 Jan 20;42(3):355-7.
3. Ruiz S, et al. Mol Cancer Ther. 2006 Jul;5(7):1836-43.
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