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Chemical Structure : Masitinib mesylate
CAS No.: 1048007-93-7
Catalog No.: PC-42455Not For Human Use, Lab Use Only.
A potent tyrosine kinase inhibitor targeting c-Kit and PDGFR with IC50 of 0.15 and 0.05 uM in cell based assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $88 | In stock | |
| 100 mg | $134.4 | In stock |
Bulk size, bulk discount!
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A potent tyrosine kinase inhibitor targeting c-Kit and PDGFR with IC50 of 0.15 and 0.05 uM in cell based assays; also inhibits Lyn, and to a lesser extent, FGFR3, and inhibits KIT gain-of-function mutants V559D (IC50=3.0 nM) and Δ27 mouse mutant (IC50=5 nM); dose-dependently inhibits SCF-induced cell proliferation in Ba/F3 cells expressing human wild-type KIT (IC50=150 nM); inhibits tumour growth in vivo.
Prostate cancer
Phase 3 Clinical
| M.Wt | 594.748 | |
| Formula | C29H34N6O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]-, methanesulfonate (1:1) |
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1. Dubreuil P, et al. PLoS One. 2009 Sep 30;4(9):e7258.
2. Humbert M, et al. Allergy. 2009 Aug;64(8):1194-201.
3. Tebib J, et al. Arthritis Res Ther. 2009;11(3):R95.
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