| Cat. No. |
Product Name |
Information |
| PC-20159 |
M4205
KIT mutations inhibitor
|
M4205 (Velzatinib, IDRX-42) is a potent, highly selective inhibitor of KIT mutations with cell IC50 of 52 nM on cKIT autophosphorylation in the GIST430/654 cell line. |
| PC-20030 |
BLU-263
KIT D816V inhibitor
|
Elenestinib (BLU-263, BLU263) is a potent, selective, oral next-generation KIT D816V inhibitor with IC50 of 0.2 nM. |
| PC-73407 |
Bezuclastinib
mutated KIT inhibitor
|
Bezuclastinib (CGT9486, PLX9486) is a potent, selective tyrosine kinase inhibitor (TKI) targeting mutated KIT and demonstrating potent activity in vitro against primary exon 9 and 11 mutations, as well as secondary exon 17 and 18 mutations. |
| PC-35661 |
AZD3229
pan-KIT mutant inhibitor
|
AZD3229 (Ubavitinib) is a potent, pan-KIT mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI50=1-50 nM). |
| PC-35619 |
BPR1J373
Multikinase inhibitor
|
BPR1J373 is a potent, orally available multitargeted kinase inhibitor, potently inhibits FLT3, c-KIT, VEGFR1-3, Aurora A, PDGFRα, PDGFRβ, RET, and SRC with IC50 values of <100 nM. |
| PC-62597 |
Famitinib
Multikinase inhibitor
|
Famitinib (SHR1020) is a structural analogue of sunitinib, novel and potent multi-targeted RTK inhibitor, including c-Kit, VEGFR2/3, PDGFRβ, FLT-1/3 receptor and c-RET. |
| PC-62536 |
CHMFL-KIT-031
KIT V559D mutant inhibitor
|
CHMFL-KIT-031 is a highly selective KIT kinase primary V559D mutant inhibitor with IC50/Kd of 28/266 nM, 10-20 fold selectivity over KIT wt. |
| PC-62101 |
DCC-2618
KIT inhibitor
|
DCC-2618 (Ripretinib) is a potent, oral inhibitor of singly and doubly mutated KIT with IC50 of WT (IC50=4 nM), V654A (8 nM), T670I (18 nM), D816H (5 nM), D816V. |
| PC-62100 |
Avapritinib
mutant KIT/PDGFRα inhibitor
|
Avapritinib (BLU-285) is a potent and highly selective inhibitor of mutant KIT and PDGFRα with IC50 of 0.6, 0.27 and 0.24 nM for KIT del557-558, KIT D816V and PDGFRA D842V, respectively. |
| PC-60152 |
KBP-7018 hydrochloride
Multikinase inhibitor
|
KBP-7018 hydrochloride is a potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively. |
| PC-60151 |
KBP-7018
Multikinase inhibitor
|
KBP-7018 is a potent, multikinase inhibitor with IC50 of 10, 7.6 and 25 nM for c-Kit, RET and PDGFRβ, respectively. |
| PC-42389 |
ISCK03
c-Kit inhibitor
|
ISCK03 is a specific c-Kit inhibitor that inhibits c-kit phosphorylation in vitro and SCF-induced c-kit phosphorylation in human melanoma cells. |
