Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Metarrestin
CAS No.: 1443414-10-5
Catalog No.: PC-35083Not For Human Use, Lab Use Only.
Metarrestin (ML246) is a specific inhibitor of perinuclear compartment (PNC), disrupts PNCs in PC3M-GFP-PTB cells with IC50 of 0.39 uM, specifically binds eEF1A2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $178 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Metarrestin (ML246) is a specific inhibitor of perinuclear compartment (PNC), disrupts PNCs in PC3M-GFP-PTB cells with IC50 of 0.39 uM, specifically binds eEF1A2.
Metarrestin (ML246) reduces PNC prevalence in different human cancer cell lines at 1 uM (IC100 for PC3M cells) for 24 hours.
Metarrestin (ML246) disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, by interacting with the translation elongation factor eEF1A2inhibits cancer cell invasion in vitro, suppresses metastatic development in three mouse models of human cancer, and extends survival of mice in a metastatic pancreatic cancer xenograft model with no organ toxicity or discernable adverse effects.
| M.Wt | 474.608 | |
| Formula | C31H30N4O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Trans-4-(7-benzyl-4-imino-5,6-diphenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl) cyclohexanol |
|
1. Frankowski KJ, et al. Sci Transl Med. 2018 May 16;10(441). pii: eaap8307.
2. Frankowski K, et al. Discovery and Development of Small Molecules That Reduce PNC Prevalence.Probe Reports from the NIH Molecular Libraries Program [Internet].
3. Rocchi A, et al. PLoS Genet. 2017 Aug 14;13(8):e1006962.
4. Kuramoto K, et al. Autophagy. 2016 Sep;12(9):1460-71.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
