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Chemical Structure : Methyl Gerfelin
Catalog No.: PC-62074Not For Human Use, Lab Use Only.
Methyl Gerfelin (M-GFN) is an osteoclastogenesis inhibitor (IC50=2.8 uM) through the competitive inhibition of glyoxalase I (GLO1) with Ki of 0.23 uM.
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Methyl Gerfelin (M-GFN) is an osteoclastogenesis inhibitor (IC50=2.8 uM) through the competitive inhibition of glyoxalase I (GLO1) with Ki of 0.23 uM; inhibits osteoclast differentiation, suppresses osteoclastogenesis with no influence on the phagocytic ability of BMMs; significantly increases intracellular methylglyoxal (MG) levels in BMMs; also inhibits P. falciparum GLO1.
| M.Wt | 304.298 | |
| Formula | C16H16O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kawatani M, et al. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11691-6.
2. Urscher M, et al. Mol Microbiol. 2010 Apr;76(1):92-103.
3. Kanoh N, et al. Bioconjug Chem. 2013 Jan 16;24(1):44-52.
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