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Chemical Structure : Mezigdomide
CAS No.: 2259648-80-9
Catalog No.: PC-38086Not For Human Use, Lab Use Only.
Mezigdomide (CC-92480) is a novel cereblon E3 ubiquitin ligase modulator (CELMoD) with high affinity to cereblon, resulting in potent antimyeloma activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $398 | In stock | |
| 50 mg | $858 | In stock | |
| 100 mg | $1380 | In stock | |
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| 1 g | Get quote |
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Mezigdomide (CC-92480) is a novel cereblon E3 ubiquitin ligase modulator (CELMoD) with high affinity to cereblon, resulting in potent antimyeloma activity.
CC-92480 selectively degrades IKZF1 and ZFP91 in TCL cells with greater potency than pomalidomide.
CC-92480 is highly active against multiple TCL subtypes and showed greater efficacy than pomalidomide across 4 in vivo TCL models.
| M.Wt | 567.621 | |
| Formula | C32H30FN5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile |
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1. Hansen JD, et al. J Med Chem. 2020 Jul 9;63(13):6648-6676.
2. Wu W, et al. Blood. 2021 Dec 22:blood.2021014701.
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