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Chemical Structure : Microcystin-LR
CAS No.: 101043-37-2
Catalog No.: PC-47481Not For Human Use, Lab Use Only.
Microcystin-LR (MC-LR) is a potent, selective inhibitor of protein phosphatase 2A (PP2A) with IC50 of 0.04 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 ug | $288 | In stock | |
| 500 ug | $488 | In stock | |
| 1 mg | $788 | In stock | |
| 5 mg | Get quote |
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Microcystin-LR (MC-LR) is a potent, selective inhibitor of protein phosphatase 2A (PP2A) with IC50 of 0.04 nM.
Microcystin-LR completely inhibits PP2A without affecting PP1 when used at a concentration of 0.5 nM, at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid; PP1 IC50 is about 1.7 nM.
Microcystin-LR shows cytotoxic activity against pancreatic cancer cells.
Microcystin-LR also induces MMP-13 expression, promotes colorectal cancer invasion and migration.
| M.Wt | 995.1716 | |
| Formula | C49H74N10O12 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
Ethanol:0.5 mg/ml |
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| Chemical Name/SMILES |
Cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl] |
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1. Honkanen RE, et al. J Biol Chem. 1990 Nov 15;265(32):19401-4.
2. Kounnis V, et al. Anticancer Res. 2015 Nov;35(11):5857-65.
3. Miao C, et al. Mol Carcinog. 2016 May;55(5):514-24.
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