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Chemical Structure : Mito-LND
CAS No.: 2361564-49-8
Catalog No.: PC-21018Not For Human Use, Lab Use Only.
Mito-LND (Mito-lonidamine) is a tumor-selective inhibitor of oxidative phosphorylation with IC50 of 1.2 and 2.4 uM for mitochondrial complexes I and II, respectively, impacts the activity of mitochondrial complexes, ROS generation and peroxiredoxin oxidation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $558 | In stock | |
| 25 mg | $898 | In stock | |
| 100 mg | Get quote |
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Mito-LND (Mito-lonidamine) is a tumor-selective inhibitor of oxidative phosphorylation with IC50 of 1.2 and 2.4 uM for mitochondrial complexes I and II, respectively, impacts the activity of mitochondrial complexes, ROS generation and peroxiredoxin oxidation.
Mito-LND shows 100-fold more potent than lonidamine (LND).
Mito-LND inhibits mitochondrial bioenergetics in lung cancer cells and mitigates lung cancer cell viability, growth, progression, and metastasis of lung cancer xenografts in mice.
Mito-LND blocks lung tumor development and brain metastasis by inhibiting mitochondrial bioenergetics, stimulating the formation of reactive oxygen species, oxidizing mitochondrial peroxiredoxin, inactivating AKT/mTOR/p70S6K signaling, and inducing autophagic cell death in lung cancer cells.
Mito-LND is selective for cancer cells and tumor tissue, does not induce autophagy in normal lung and brain tissue or normal lung cell lines.
| M.Wt | 801.63 | |
| Formula | C43H45BrCl2N3OP | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Phosphonium, [10-[[[1-[(2,4-dichlorophenyl)methyl]-1H-indazol-3-yl]carbonyl]amino]decyl]triphenyl-, bromide (1:1) |
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1. Gang Cheng, et al. Nat Commun. 2019 May 17;10(1):2205.
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