Chemical Structure : MitoSNO
CAS No.:
1187336-50-0
MitoSNO
(Mitochondria-targeted S-nitrosothiol)
Catalog No.: PC-24382Not For Human Use, Lab Use Only.
MitoSNO (mitochondria-targeted S-nitrosothiol) is a mitochondria-selective S-nitrosating agent, selectively S-nitrosates mitochondrial proteins.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MitoSNO (mitochondria-targeted S-nitrosothiol) is a mitochondria-selective S-nitrosating agent, selectively S-nitrosates mitochondrial proteins.
MitoSNO inhibits mitochondrial hydrogen peroxide (mtH2O2) generation by α-ketoglutarate dehydrogenase (KGDH)
MitoSNO also suppressed mtH2O2 production and partially rescued mitochondrial respiration in Huh-7 cells subjected to palmitate (PA) and fructose (Fruc) induced lipotoxicity.
MitoSNO protects against acute ischaemia/reperfusion (IR) injury by inhibiting the reactivation of mitochondrial complex I.
Physicochemical Properties
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M.Wt
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645.77
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Formula
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C31H40N3O6PS2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Phosphonium, [5-[[2-(acetylamino)-3-methyl-3-(nitrosothio)-1-oxobutyl]amino]pentyl]triphenyl-, methanesulfonate (1:1)
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References
1. Chouchani ET, et al. Biochem J. 2010 Aug 15;430(1):49-59.
2. Chouchani ET, et al. Nat Med. 2013 Jun;19(6):753-9.
3. Methner C, et al. Eur J Heart Fail. 2014 Jul;16(7):712-7.
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