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Chemical Structure : Mitoquinone mesylate
CAS No.: 845959-50-4
Catalog No.: PC-21381Not For Human Use, Lab Use Only.
Mitoquinone mesylate (MitoQ) is a potent inhibitor of TRAP1 activity in cancer cells with IC50 of 0.2 uM in 22Rv1 cells, reduces SDHB and SIRT3 and increases phosphor-AMPK and CHOP.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $568 | In stock | |
| 100 mg | Get quote |
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Mitoquinone mesylate (MitoQ) is a potent inhibitor of TRAP1 activity in cancer cells with IC50 of 0.2 uM in 22Rv1 cells, reduces SDHB and SIRT3 and increases phosphor-AMPK and CHOP.
MitoQ potently disrupted the mitochondrial membrane potential (TMRM staining) and elevated ROS production (Mito-SOX staining) and consequently induced mitochondrial fragmentation and elevated cytoplasmic calcium levels in cancer cells.
MitoQ, in combination with mitoquinol, reduces malondialdehyde (MDA) levels in isolated rat liver mitochondria and decreases caspase activity in Jurkat cells.
MitoQ alleviates retinal pathologies via proteolytic HIF1α degradation, which is mediated by opening of the mitochondrial permeability transition pore and activation of calcium-dependent protease calpain-1.
| M.Wt | 678.81 | |
| Formula | C38H47O7PS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl)triphenylphosphonium methanesulfonate |
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1. So-Yeon Kim, et al. Adv Sci (Weinh). 2023 Nov 20:e2302776.
2. Kelso GF, et al. Ann N Y Acad Sci. 2002.
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