Chemical Structure : MyD88 inhibitor 15d
CAS No.:
2249864-11-5
MyD88 inhibitor 15d
Catalog No.: PC-21179Not For Human Use, Lab Use Only.
MyD88 inhibitor 15d is a potent, small molecule inhibitor of MyD88 homodimerization, dose-dependently inhibits LPS-induced IL-6 and TNF-α in macrophages with IC50 of 2.52 and 0.89 uM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MyD88 inhibitor 15d is a potent, small molecule inhibitor of MyD88 homodimerization, dose-dependently inhibits LPS-induced IL-6 and TNF-α in macrophages with IC50 of 2.52 and 0.89 uM, respectively.
MyD88 inhibitor 15d prevents LPS-induced activation of MAPK and NF-κB signaling pathways.
MyD88 inhibitor 15d (10 mg/kg) protects against LPS-induced acute lung injury in mice, protects against pulmonary inflammation on histopathological changes in lung tissues of mice challenged with LPS.
Physicochemical Properties
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M.Wt
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497.57
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Formula
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C24H27N5O5S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-(4-hydroxy-3-methoxyphenyl)thiazol-2-yl)-3-(4-(3-nitrobenzyl)piperazin-1-yl)propanamide
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References
1. Lingfeng Chen, et al. Eur J Med Chem. 2019 Jan 1;161:22-38.
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