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Chemical Structure : MyD88 inhibitor 15d
Catalog No.: PC-21179Not For Human Use, Lab Use Only.
MyD88 inhibitor 15d is a potent, small molecule inhibitor of MyD88 homodimerization, dose-dependently inhibits LPS-induced IL-6 and TNF-α in macrophages with IC50 of 2.52 and 0.89 uM, respectively.
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MyD88 inhibitor 15d is a potent, small molecule inhibitor of MyD88 homodimerization, dose-dependently inhibits LPS-induced IL-6 and TNF-α in macrophages with IC50 of 2.52 and 0.89 uM, respectively.
MyD88 inhibitor 15d prevents LPS-induced activation of MAPK and NF-κB signaling pathways.
MyD88 inhibitor 15d (10 mg/kg) protects against LPS-induced acute lung injury in mice, protects against pulmonary inflammation on histopathological changes in lung tissues of mice challenged with LPS.
| M.Wt | 497.57 | |
| Formula | C24H27N5O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lingfeng Chen, et al. Eur J Med Chem. 2019 Jan 1;161:22-38.
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