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Chemical Structure : Myriocin
CAS No.: 35891-70-4
Catalog No.: PC-61423Not For Human Use, Lab Use Only.
Myriocin (ISP-1) is an amino fatty acid antibiotic that is 10- to 100-fold more potent than cyclosporin A as an immunosuppressive agent of the immune response in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | $658 | In stock | |
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| 1 g | Get quote |
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Myriocin (ISP-1) is an amino fatty acid antibiotic that is 10- to 100-fold more potent than cyclosporin A as an immunosuppressive agent of the immune response in vitro and in vivo.
Myriocin (ISP-1) is a potent inhibitor of serine palmitoyltransferase (SPT) with Ki of 0.28 nM.
Myriocin (ISP-1) inhibits the proliferation of IL-2-dependent mouse cytotoxic T cell line CTLL-2 (IC50=15 nM) by the modulation of sphingolipid metabolism.
| M.Wt | 401.5 | |
| Formula | C21H39NO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid |
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1. Fujita T, et al. J Antibiot (Tokyo). 1994 Feb;47(2):208-15.
2. Miyake Y, et al. Biochem Biophys Res Commun. 1995 Jun 15;211(2):396-403.
3. Nakamura S, et al. J Biol Chem. 1996 Jan 19;271(3):1255-7.
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