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Chemical Structure : N-acetyl lysyltyrosylcysteine amide
Catalog No.: PC-62579Not For Human Use, Lab Use Only.
N-acetyl lysyltyrosylcysteine amide (KYC) is a potent, tripeptide inhibitor of myeloperoxidase (MPO), inhibits MPO-mediated hypochlorous acid (HOCl) formation (IC50=7 uM) and nitration/oxidation of LDL.
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N-acetyl lysyltyrosylcysteine amide (KYC) is a potent, tripeptide inhibitor of myeloperoxidase (MPO), inhibits MPO-mediated hypochlorous acid (HOCl) formation (IC50=7 uM) and nitration/oxidation of LDL; completely inhibits HOCl production at 25 uM, decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice; reduces oxidative stress-mediated inflammation, neuronal damage, and neural stem cell injury in murine model of stroke.
| M.Wt | ||
| Formula | C20H31N5O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang H, et al. J Lipid Res. 2013 Nov;54(11):3016-29.
2. Zhang H, et al. J Lipid Res. 2013 Nov;54(11):3009-15.
3. Yu G, et al. J Neuroinflammation. 2016 May 24;13(1):119.
4. Rymaszewski AL, et al. Cancers (Basel). 2014 May 9;6(2):1111-27.
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