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Chemical Structure : NB-598 maleate
CAS No.: 155294-62-5
Catalog No.: PC-49756Not For Human Use, Lab Use Only.
NB-598 (NB598) is a potent competitive inhibitor of squalene epoxidase (SQLE, SE, squalene monooxygenase) with IC50 of 4.4 nM (rat SE), inhibits microsomal squalene epoxidase from dog liver and Hep G2 cells with IC50 of 2.0 and 0.75 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $258 | In stock | |
| 50 mg | $448 | In stock | |
| 100 mg | $758 | In stock | |
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NB-598 (NB598) is a potent competitive inhibitor of squalene epoxidase (SQLE, SE, squalene monooxygenase) with IC50 of 4.4 nM (rat SE), inhibits microsomal squalene epoxidase from dog liver and Hep G2 cells with IC50 of 2.0 and 0.75 nM, respectively.
NB-598 also strongly inhibited cholesterol synthesis from [14C]acetate in Hep G2 cells with an ICso value of 3.4 nM.
NB-598 inhibited cholesterol synthesis from [14C]acetate dose dependently in Hep G2 cells and increased the intracellular radioactivity of squalene.
A single oral administration of NB-598 inhibited cholesterol synthesis from [14C]acetate in rats.
Multiple oral administration of NB-598 to dogs decreased serum total and low density lipoprotein cholesterol levels and increased serum squalene levels.
| M.Wt | 565.74 | |
| Formula | C31H35NO5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzenemethanamine, 3-([3,3′-bithiophen]-5-ylmethoxy)-N-[(2E)-6,6-dimethyl-2-hepten-4-ynyl]-N-ethyl-, (2Z)-2-butenedioate (1:1) |
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1. Nakamura Y, et al. J Biol Chem. 1996 Apr 5;271(14):8053-6.
2. Horie M, et al. J Biol Chem. 1990 Oct 25;265(30):18075-8.
3. Hidaka Y, et al. J Biol Chem. 1991 Jul 15;266(20):13171-7.
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