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Chemical Structure : NC1153
Catalog No.: PC-61264Not For Human Use, Lab Use Only.
A Mannich base compound, selective and orally active JAK3 inhibitor that blocks IL-2-induced activation of JAK3 and downstream substrates STAT5a/b.
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A Mannich base compound, selective and orally active JAK3 inhibitor that blocks IL-2-induced activation of JAK3 and downstream substrates STAT5a/b; fails to inhibit several other enzymes, including growth factor receptor tyrosine kinases, Src family members, and serine/threonine protein kinases; inhibits proliferation of normal human T cells challenged with IL-2, IL-4, or IL-7; significantly extends survival of MHC/non-MHC mismatched rat kidney allografts, induces transplantation tolerance in vivo.
| M.Wt | 369.415 | |
| Formula | C18H38Cl2N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stepkowski SM, et al. J Immunol. 2005 Oct 1;175(7):4236-46.
2. Nagy ZS, et al. Mol Cancer. 2009 Aug 26;8:67.
3. Nagy ZS, et al. FEBS Lett. 2010 Apr 16;584(8):1515-20.
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