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Chemical Structure : NCI-41356
Catalog No.: PC-20883Not For Human Use, Lab Use Only.
NCI-41356 is a small molecular inhibitor of αB-crystallin (CRYAB, HSPB5), significantly reducesthe interaction between CRYAB and VEGF165.
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NCI-41356 is a small molecular inhibitor of αB-crystallin (CRYAB, HSPB5), significantly reducesthe interaction between CRYAB and VEGF165.
NCI-41356 (10-50 uM) decreases the malignant behaviour of breast tumour cells MDA-MB-231 and MDA-MB-436, does not alter CRYAB expression levels.
NCI-41356 (200 mg/kg, i.p.) greatly inhibits the tumour growth and vasculature development in in vivo human breast cancer xenograft models.
| M.Wt | 197.62 | |
| Formula | C6H12ClNO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen Z, et al. Breast Cancer Res Treat. 2014 May;145(1):45-59.
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