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Chemical Structure : NGI-1 derivative C-19
Catalog No.: PC-35568Not For Human Use, Lab Use Only.
NGI-1 derivative C-19 is a specific, small-molecule inhibitor of oligosaccharyltransferase (OST) catalytic subunit STT3B, without effect on STT3A.
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NGI-1 derivative C-19 is a specific, small-molecule inhibitor of oligosaccharyltransferase (OST) catalytic subunit STT3B, without effect on STT3A.
NGI-1 derivative C-19 reduces ligand stimulated activation of EGFR, in STT3A-ko cells, where EGFR glycosylation is dependent on STT3B alone, does not reduce glycosylation and ligand stimulation of EGFR in parental and STT3B-ko cells.
NGI-1 derivative C-19 has discrete biological effects on endogenous STT3B target proteins such as COX2 but does not activate the cellular unfolded protein response (UPR).
| M.Wt | 415.508 | |
| Formula | C21H25N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rinis N, et al. Cell Chem Biol. 2018 Jul 24. pii: S2451-9456(18)30232-0.
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