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Chemical Structure : NIBR-0213
CAS No.: 1233332-14-3
Catalog No.: PC-61179Not For Human Use, Lab Use Only.
NIBR-0213 is a potent, selective, orally active S1P1 antagonist with IC50 of 2.5 nM Ca2+ mobilization assays, without activity on S1P2, S1P3 and S1P4 (IC50>10 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $548 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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NIBR-0213 is a potent, selective, orally active S1P1 antagonist with IC50 of 2.5 nM Ca2+ mobilization assays, without activity on S1P2, S1P3 and S1P4 (IC50>10 uM).
NIBR-0213 displays potent and comparable potency on human and rat S1P1 with IC50 of 2.0 and 2.3 nM in GTPγ35S assays, 3,000-fold selectivity against human S1P5.
NIBR-0213 inhibits FTY720-phosphate-induced S1P1 internalization at 1 uM, induces long-lasting reduction of peripheral blood lymphocyte counts, shows comparable therapeutic efficacy to Fingolimod in experimental autoimmune encephalomyelitis (EAE).
| M.Wt | 465 | |
| Formula | C27H29ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[[3'-[[(1R)-1-(4-chloro-3-methylphenyl)ethyl]amino]-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]-L-alanine |
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1. Quancard J, et al. Chem Biol. 2012 Sep 21;19(9):1142-51.
2. Bigaud M, et al. PLoS One. 2016 Dec 22;11(12):e0168252.
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