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Chemical Structure : NLX-101
CAS No.: 635323-95-4
Catalog No.: PC-73308Not For Human Use, Lab Use Only.
NLX-101 (F15599) is a potent, highly selective post-synaptic 5-HT1A receptor agonist with Ki of 3.4 nM.
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| 25 mg | $548 | In stock | |
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NLX-101 (F15599) is a potent, highly selective post-synaptic 5-HT1A receptor agonist with Ki of 3.4 nM.
NLX-101 (F15599) is over 1000-fold selective with respect to the other 5-HT1 receptor subtypes, 5-HT2-7 receptor families, and also numerous GPCRs, transporters, ion channels, and enzymes.
NLX-101 (F15599) activates h5-HT1A receptors with an efficacy superior to that of the prototypical 5-HT1A agonist (+/-)-8-OH-DPAT in cellular model of signal transduction.
NLX-101 (F15599), unlike 5-HT, more potently and efficaciously stimulated G(αi) than G(αo) activation.
NLX-101 (F15599) potently activated ERK1/2 phosphorylation and strongly induced c-fos mRNA expression in rat prefrontal cortex.
NLX-101 (F15599) attenuates muscular hyperalgesia in reserpine-induced myalgia model.
| M.Wt | 394.85 | |
| Formula | C19H21ClF2N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3-Chloro-4-fluorophenyl)[4-fluoro-4-[[[(5-methyl-2-pyrimidinyl)methyl]amino]methyl]-1-piperidinyl]methanone |
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1. Maurel JL, et al. J Med Chem. 2007 Oct 4;50(20):5024-33.
2. Newman-Tancredi A, et al. Br J Pharmacol. 2009 Jan;156(2):338-53.
3. Assié MB, et al. Int J Neuropsychopharmacol. 2010 Nov;13(10):1285-98.
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