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Chemical Structure : NLX-204
Catalog No.: PC-36071Not For Human Use, Lab Use Only.
NLX-204 (NLX204) is a potent, selective, ERK1/2 phosphorylation-preferring serotonin 5-HT1A receptor agonist with pEC50 of 9.37.
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NLX-204 (NLX204) is a potent, selective, ERK1/2 phosphorylation-preferring serotonin 5-HT1A receptor agonist with pEC50 of 9.37.
NLX-204 shows promising pharmacokinetic profile, also robustly stimulates ERK1/2 phosphorylation in rat cortex and showed highly potent (MED=0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.
| M.Wt | 409.862 | |
| Formula | C20H22ClF2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sniecikowska J, et al. J Med Chem. 2019 Feb 5. doi: 10.1021/acs.jmedchem.9b00062.
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