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NLX-204

Chemical Structure : NLX-204

CAS No.: 2170405-10-2

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NLX-204 (NLX204, NLX 204)

Catalog No.: PC-36071Not For Human Use, Lab Use Only.

NLX-204 (NLX204) is a potent, selective, ERK1/2 phosphorylation-preferring serotonin 5-HT1A receptor agonist with pEC50 of 9.37.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NLX-204 (NLX204) is a potent, selective, ERK1/2 phosphorylation-preferring serotonin 5-HT1A receptor agonist with pEC50 of 9.37.
    NLX-204  shows promising pharmacokinetic profile, also robustly stimulates ERK1/2 phosphorylation in rat cortex and showed highly potent (MED=0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.

    Physicochemical Properties

    M.Wt 409.862
    Formula C20H22ClF2N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3-chloro-4-fluorophenyl)(4-fluoro-4-(((2-(pyridin-2-yloxy)ethyl)amino)methyl)piperidin-1-yl)methanone

    References

    1. Sniecikowska J, et al. J Med Chem. 2019 Feb 5. doi: 10.1021/acs.jmedchem.9b00062.

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