Chemical Structure : NLX-266
CAS No.:
2170564-20-0
NLX-266
(NLX266)
Catalog No.: PC-24462Not For Human Use, Lab Use Only.
NLX-266 is a potent, selective, orally available and metabolically stable ERK1/2-biased 5-HT1A receptor agonist with binding pKi of 10.35, >1000-fold selective over adrenergic α1 and dopaminergic D2 receptors.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NLX-266 is a potent, selective, orally available and metabolically stable ERK1/2-biased 5-HT1A receptor agonist with binding pKi of 10.35, >1000-fold selective over adrenergic α1 and dopaminergic D2 receptors.
NLX-266 preferentially activates ERK1/2 phosphorylation, correlating with significant antidepressant effects in the forced swim test in rats at low doses (MED = 0.63 mg/kg p.o.).
NLX-266 demonstrates potent antiparkinsonian effects by reversing haloperidol-induced catalepsy at very low doses (MED = 0.04 mg/kg p.o.).
Physicochemical Properties
|
M.Wt
|
427.85
|
|
Formula
|
C20H21ClF3N3O2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(3-Chloro-4-fluorophenyl)(4-fluoro-4-(((2-((4-fluoropyridin-2-yl)oxy)ethyl)amino)methyl)piperidin-1-yl)methanone
|
References
1. Sniecikowska J, et al. J Med Chem. 2025 Apr 23. doi: 10.1021/acs.jmedchem.5c00484.
Contact Us
sales@probechem.com
