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NMS-873

Chemical Structure : NMS-873

CAS No.: 1418013-75-8

NMS-873 (NMS873, VCP Inhibitor III)

Catalog No.: PC-38468Not For Human Use, Lab Use Only.

NMS-873 (NMS873) is a potent, specific, cell-permeable, non-ATP competitive, allosteric inhibitor of VCP/p97 ATPase with IC50 of 30 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NMS-873 (NMS873) is a potent, specific, cell-permeable, non-ATP competitive, allosteric inhibitor of VCP/p97 ATPase with IC50 of 30 nM.
NMS-873 displays high selectivity over all other AAA ATPases, HSP90 and kinases tested at 10 uM.
NMS-873 activates the unfolded protein response (UPR), interferes with autophagy and induced cancer cell death.
p97 A530T mutant is sufficient to overcome the cytotoxicity of NMS-873 and alleviates p97 composition changes caused by the molecule but not other p97 inhibitors.
NMS-873 also is a potent HCMV antiviral with potential for HCMV infection via host VCP/p97 inhibition.
NMS-873 exhibits antiproliferative activity in cancer cells in vitro (IC50= 400 and 700 nM for HCT116 and HeLa cells respectively).

Physicochemical Properties

M.Wt 520.666
Formula C27H28N4O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[3-(Cyclopentylthio)-5-[[[2-methyl-4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine

References

1. Magnaghi P, et al. Nat Chem Biol. 2013 Sep;9(9):548-56.

2. Daniel J Anderson, et al. Cancer Cell. 2015 Nov 9;28(5):653-665.

3. Her NG, et al. Cell Chem Biol. 2016 Apr 21;23(4):517-28.

4. Lin YT, et al. PLoS Pathog. 2017 May 11;13(5):e1006329.

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