Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NMS-P645
Catalog No.: PC-63141Not For Human Use, Lab Use Only.
NMS-P645 is a potent, selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NMS-P645 is a potent, selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively.
NMS-P645 exhibits excellent selectivity against a large panel of kinases.
NMS-P645 reverse PIM1-mediated pro-survival signals in prostate cells, such as activation of STAT3 through Tyr705 phosphorylation and resistance to taxane-based treatments.
NMS-P645 induces a significant anti-proliferative response in PCa cells combined with GDC-0941.
| M.Wt | 512.095 | |
| Formula | C28H38ClN5O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Casuscelli F, et al. Bioorg Med Chem. 2013 Dec 1;21(23):7364-80.
2. Mologni L, et al. J Cancer. 2017 Jan 1;8(1):140-145.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
