Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NMac1
Catalog No.: PC-35500Not For Human Use, Lab Use Only.
NMac1 (Nm23 activator 1) is a small molecule activator of Nm23/NDPK, directly binds to Nm23-H1 and activates NDPK activity of recombinant Nm23-H1 with EC50 of 10.7 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NMac1 (Nm23 activator 1) is a small molecule activator of Nm23/NDPK, directly binds to Nm23-H1 and activates NDPK activity of recombinant Nm23-H1 with EC50 of 10.7 uM.
NMac1 binds to the C-terminal of Nm23-H1 and induces the NDPK activation through its allosteric conformational changes.
NMac1-treated MDA-MB-231 breast cancer cells showed dramatic changes in morphology and actin-cytoskeletal organization following inhibition of Rac1 activation.
NMac1 also suppressed invasion and migration in vitro, and metastasis in vivo, in a breast cancer mouse model.
| M.Wt | 380.484 | |
| Formula | C24H28O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Lee JJ, et al. Sci Rep. 2018 Jul 19;8(1):10909.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
