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Chemical Structure : NP-C86
Catalog No.: PC-49043Not For Human Use, Lab Use Only.
NP-C86 is a small molecule that limits the degradation of GAS5 by blocking the interaction of long noncoding RNA (lncRNA) GAS5 and UPF1. NP-C86 binds to GAS5 with high affinity (Kd=153 nM) and stabilize GAS5 levels in vivo.
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NP-C86 is a small molecule that limits the degradation of GAS5 by blocking the interaction of long noncoding RNA (lncRNA) GAS5 and UPF1. NP-C86 binds to GAS5 with high affinity (Kd=153 nM) and stabilize GAS5 levels in vivo.
NP-C86 (20 nM, 24 hours) dramatically reduces (4-fold) the association between UPF1 and GAS5, increases GAS5 levels and glucose uptake in diabetes mellitus (DM) adipocytes.
NP-C86 is specific for lncRNA GAS5, does not affect levels of MALAT1 or NEAT1, the other lncRNAs present in the adipocytes.
NP-C86 restores insulin-mediated glucose uptake in DM adipocytes.
| M.Wt | 1225.605 | |
| Formula | C68H92N10O9S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yan Shi, et al. Cell Chem Biol. 2019 Mar 21;26(3):319-330.e6.
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