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Chemical Structure : NP161
Catalog No.: PC-35583Not For Human Use, Lab Use Only.
NP161 is a potent and selective inhibitor of extracellular TRX (Thioredoxin 1) in vitro with IC50 of 0.54 uM.
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NP161 is a potent and selective inhibitor of extracellular TRX (Thioredoxin 1) in vitro with IC50 of 0.54 uM.
NP161 enhances cytokine outputs of alternatively activated macrophages, significantly attenuate TG2 activity and 5-BP incorporation in both M0 and M1 macrophages.
| M.Wt | 309.402 | |
| Formula | C13H15N3O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Plugis NM, et al. Proc Natl Acad Sci U S A. 2018 Aug 13. pii: 201805288.
2. DiRaimondo TR, et al. J Med Chem. 2013 Feb 14;56(3):1301-10.
3. Plugis NM, et al. J Biol Chem. 2017 Feb 3;292(5):2000-2008.
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