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Chemical Structure : NPAS3 inhibitor 6
Catalog No.: PC-21007Not For Human Use, Lab Use Only.
NPAS3 inhibitor 6 is a highly potent neuronal PAS domain protein 3 (NPAS3) inhibitor with IC50 of 282 nM, blocks the NPAS3-ARNT heterodimerization by covalently conjugating ARNT Cys336 residue.
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NPAS3 inhibitor 6 is a highly potent neuronal PAS domain protein 3 (NPAS3) inhibitor with IC50 of 282 nM, blocks the NPAS3-ARNT heterodimerization by covalently conjugating ARNT Cys336 residue.
NPAS3 inhibitor 6 effectively down-regulated NPAS3's transcriptional function by disrupting the interface of NPAS3-ARNT complexes at cellular level.
Neuronal PAS domain protein 3 (NPAS3), a basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) family member, is a pivotal transcription factor in neuronal regeneration, development, and related diseases, regulating the expression of downstream genes.
| M.Wt | 295.35 | |
| Formula | C10H5N3O2S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li P, et al. Bioorg Chem. 2023 Jun 10;139:106676.
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