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Chemical Structure : NR5A2 inhibitor Cmp3d2
Catalog No.: PC-21459Not For Human Use, Lab Use Only.
NR5A2 inhibitor Cmp3d2 is a specific small molecule inhibitor of NR5A2 (liver receptor homolog-1, LRH-1) with Kd of 1.8 uM in Biacore-based assays, inhibits the transcriptional activity of hLRH-1 with IC50 of 6 uM (G0S2 mRNA level).
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NR5A2 inhibitor Cmp3d2 is a specific small molecule inhibitor of NR5A2 (liver receptor homolog-1, LRH-1) with Kd of 1.8 uM in Biacore-based assays, inhibits the transcriptional activity of hLRH-1 with IC50 of 6 uM (G0S2 mRNA level).
NR5A2 inhibitor Cmp3d2 reduces tumor necrosis factor (TNF) production and associated decreased liver damage in a macrophage- and TNF-dependent mouse model of hepatitis.
| M.Wt | 364.50 | |
| Formula | C21H28N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cindy Benod, et al. J Biol Chem. 2013 Jul 5;288(27):19830-44.
2. Juliane Schwaderer, et al. Cell Death Dis. 2020 Feb 28;11(2):154.
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