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Chemical Structure : NS-3-008
CAS No.: 1172854-54-4
Catalog No.: PC-61825Not For Human Use, Lab Use Only.
NS-3-008 is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $358 | In stock | |
| 25 mg | $658 | In stock | |
| 100 mg | Get quote |
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NS-3-008 is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM; decreases levels of G0s2 and Ccl2 mRNA in the kidneys (5 mg/kg, p.o.); decreases the phosphorylation of Stat5 and p65 protein and suppresses renal inflammation in 5/6Nx mice, ameliorates renal dysfunction in mouse model of chronic kidney disease (CKD).
| M.Wt | 269.817 | |
| Formula | C14H24ClN3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-benzyl-3-hexylguanidine hydrochloride |
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1. Matsunaga N, et al. EBioMedicine. 2016 Nov;13:262-273.
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