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Chemical Structure : NS19504
CAS No.: 327062-46-4
Catalog No.: PC-60653Not For Human Use, Lab Use Only.
A novel selective, small molecule large-conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1, MaxiK) positive modulator with EC50 of 11 uM.
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|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
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NS19504 is a selective, small molecule large-conductance Ca(2+)-activated K(+) channel (BKCa, KCa1.1, MaxiK) positive modulator with EC50 of 11 uM.
NS19504 shows a favorable selectivity profile on Nav, Cav, SK, and IK channels.
NS19504 causes distinct activation from a concentration of 0.3 and 10 µM NS19504 left-shifted the voltage activation curve by 60 mV.
NS19504 reduces spontaneous phasic contractions in guinea pig urinary bladder strips at 1 uM, while having only a modest effect on contractions evoked by electrical field stimulation (EFS) and no effect on high K+-induced contractions.
| M.Wt | 269.16 | |
| Formula | C10H9BrN2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO |
|
| Chemical Name/SMILES |
5-[(4-bromophenyl)methyl]-1,3-thiazol-2-amine |
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1. Nausch B, et al. J Pharmacol Exp Ther. 2014 Sep;350(3):520-30.
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