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Chemical Structure : NS3623
CAS No.: 343630-41-1
Catalog No.: PC-60833Not For Human Use, Lab Use Only.
NS3623 is a novel human RBC Cl-conductance blocker (IC50=210 nM) and HERG channel activitor (EC50=79.4 uM, HERG1 channel activation).
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NS3623 is a novel human RBC Cl-conductance blocker (IC50=210 nM) and HERG channel activitor (EC50=79.4 uM, HERG1 channel activation).
NS-3623 inhibits RBC g(Cl) after oral administration to normal mice (ED50= 25 mg/kg), ameliorates erythrocyte dehydration in transgenic SAD mice.
NS-3623 increases the macroscopic current conducted by the hERG channels by increasing the time constant for channel inactivation.
NS-3623 affects native I(Kr), decreases QT variability and distinctly decreases the occurrence of extrasystoles in the acutely bradypaced hearts.
| M.Wt | 427.185 | |
| Formula | C15H10BrF3N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea |
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1. Bennekou P, et al. Blood. 2001 Mar 1;97(5):1451-7.
2. Hansen RS, et al. Mol Pharmacol. 2006 Oct;70(4):1319-29.
3. Hansen RS, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):996-1002.
4. Hansen RS, et al. J Cardiovasc Pharmacol. 2008 Jul;52(1):35-41.
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