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Chemical Structure : NS8593 hydrochloride
CAS No.: 875755-24-1
Catalog No.: PC-73222Not For Human Use, Lab Use Only.
NS8593 is a potent and selective small conductance Ca2+-activated K+ channels (SK channels) inhibitor, reversibly inhibits recombinant SK3-mediated currents with potencies around 100 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | $558 | In stock | |
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NS8593 is a potent and selective small conductance Ca2+-activated K+ channels (SK channels) inhibitor, reversibly inhibits recombinant SK3-mediated currents with potencies around 100 nM.
NS8593 decreased the Ca(2+) sensitivity by shifting the activation curve for Ca(2+) to the right, only slightly affecting the maximal Ca(2+)-activated SK current.
NS8593 inhibited all the SK1-3 subtypes Ca(2+)-dependently (Kd= 0.42, 0.60, and 0.73 uM, respectively, at 0.5 microM Ca(2+)).
NS8593 does not affect the Ca(2+)-activated K(+) channels of intermediate and large conductance (hIK and hBK channels, respectively).
| M.Wt | 299.79 | |
| Formula | C17H17N3.HCl | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Strøbaek D, et al. Mol Pharmacol. 2006 Nov;70(5):1771-82.
2. Haugaard MM, et al. Heart Rhythm. 2015 Apr;12(4):825-35.
3. Skibsbye L, et al. Cardiovasc Res. 2014 Jul 1;103(1):156-67.
4. Qi XY, et al. Circulation. 2014 Jan 28;129(4):430-40.
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