Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NSC12
Catalog No.: PC-60628Not For Human Use, Lab Use Only.
An orally active small-molecule chemical that acts as an extracellular FGF trap, binds immobilized FGF3,FGF4, FGF6, FGF8, FGF16, FGF18, FGF20, and FGF22 with Kd of 16-120 uM, inhibits FGF-dependent tumor growth, angiogenesis and metastases.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
An orally active small-molecule chemical that acts as an extracellular FGF trap, binds immobilized FGF3,FGF4, FGF6, FGF8, FGF16, FGF18, FGF20, and FGF22 with Kd of 16-120 uM, inhibits FGF-dependent tumor growth, angiogenesis and metastases; shows no apparent interaction for the other FGFs; inhibits HSPG/FGF/FGFR ternary complex formation induced by FGFR1(IIIc)-binding FGFs KATO III cells, inhibits FGFR1 phosphorylation in HUVECs stimulated by FGF2 with inhibition of HUVEC proliferation with IC50 of 6.5 uM; demonstrates significant inhibition of H520 tumor growth in vivo.
| M.Wt | 484.523 | |
| Formula | C24H34F6O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Ronca R, et al. Cancer Cell. 2015 Aug 10;28(2):225-39.
2. Castelli R, et al. J Med Chem. 2016 May 26;59(10):4651-63.
3. Ronca R, et al. Oncotarget. 2017 Aug 1;8(47):82583-82592.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
