Chemical Structure : NSC135618
CAS No.:
2253964-26-8
NSC135618
Catalog No.: PC-25591Not For Human Use, Lab Use Only.
NSC135618 is a potent, allosteric inhibitor of the flavivirus NS2B-NS3 protease, inhibits the protease of Dengue virus 2 (DENV2) in vitro with IC50 of 1.8 uM, shows broad spectrum flavivirus protease, inhibits DENV2, Zika virus (ZIKV), West Nile virus (WNV), and Yellow fever virus (YFV) on A549 cells in vivo with EC50 in low micromolar range.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NSC135618 is a potent, allosteric inhibitor of the flavivirus NS2B-NS3 protease, inhibits the protease of Dengue virus 2 (DENV2) in vitro with IC50 of 1.8 uM, shows broad spectrum flavivirus protease, inhibits DENV2, Zika virus (ZIKV), West Nile virus (WNV), and Yellow fever virus (YFV) on A549 cells in vivo with EC50 in low micromolar range.
Physicochemical Properties
|
M.Wt
|
431.23
|
|
Formula
|
C19H12Cl2N4O4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
3-(2-(2-chloro-4-nitrophenyl)hydrazineylidene)-N-(3-chlorophenyl)-6-oxocyclohexa-1,4-diene-1-carboxamide
|
References
1. Brecher M, et al. PLoS Pathog. 2017 May 25;13(5):e1006411.
Contact Us
sales@probechem.com
