Catalog No.: PC-25853Not For Human Use, Lab Use Only.
NSC228155 (NSC 228155) is a potent inhibitor of CREB-CBP interaction (IC50=0.36 uM) taregting interaction of kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, also is an activator of EGFR, binds to the extracellular region of EGFR and enhances tyrosine phosphorylation of EGFR.
NSC228155 (NSC 228155) is a potent inhibitor of CREB-CBP interaction (IC50=0.36 uM) taregting interaction of kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, also is an activator of EGFR, binds to the extracellular region of EGFR and enhances tyrosine phosphorylation of EGFR. NSC228155 inhibited the pertussis AB5 holotoxin-catalyzed ADP-ribosylation of Gαi in living human cells with IC50 of 2.4 uM. NSC228155 attenuated tumor suppressor function of ABHD11‑AS1 in in colorectal cancer (CRC) cells.
