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NSC23005 sodium

Chemical Structure : NSC23005 sodium

CAS No.: 1796596-46-7

NSC23005 sodium (NSC 23005 sodium;NSC-23005 sodium;p18-IN-40)

Catalog No.: PC-42259Not For Human Use, Lab Use Only.

A novel specific, effective p18 (p18INK4C) inhibitor that can selectively promote HSCs expansion with EC50 of 5.21 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A novel specific, effective p18 (p18INK4C) inhibitor that can selectively promote HSCs expansion with EC50 of 5.21 nM; inhibits p18, and then activates CDK4/6, promotes HSCs expansion in both murine and human models; shows no activity in promoting the proliferation of leukemia cells, and no significant cytotoxicity toward 32D cells or HSCs.

Physicochemical Properties

M.Wt 305.33
Formula C13H16NNaO4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 6.4 mg/mL (Need ultrasonic)

Chemical Name/SMILES

Benzoic acid, 4-[(cyclohexylamino)sulfonyl]-, sodium salt (1:1)

References

1. Xie XQ, et al. Sci Rep. 2015 Dec 18;5:18115.

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