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Chemical Structure : NSC 23925
Catalog No.: PC-62665Not For Human Use, Lab Use Only.
NSC 23925 is a small molecule compound that reverses multiple drug resistance (MDR) in human cancer cell lines, reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR.
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NSC 23925 is a small molecule compound that reverses multiple drug resistance (MDR) in human cancer cell lines, reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR; shows maximal reversal of resistance in SKOV-3TR or OVCAR8TR to cytotoxic drugs is 0.5 uM to 1 uM; stimulates ATPase activity of Pgp, increases the intracellular accumulation of Pgp1 substrates.
| M.Wt | 421.36 | |
| Formula | C22H26Cl2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Duan Z, et al. PLoS One. 2009 Oct 12;4(10):e7415.
2. Duan Z, et al. J Med Chem. 2012 Apr 12;55(7):3113-21.
3. Yang X, et al. Br J Cancer. 2014 Jun 10;110(12):2896-904.
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